Riding the Bus with My Sister (2005)

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Riding the Bus with My Sister is a memoir by Rachel Simon, published in 2002 by Houghton Mifflin about the time she spent with her sister Beth, who has a developmental disability, whose lifestyle revolves around riding buses in her home city.

In 2005, the book was adapted into a television film for CBS directed by Anjelica Huston in which Rosie O'Donnell appears as Beth, a woman with an intellectual disability, who is dependent on her father. When her father dies, her sister, played by Andie MacDowell, comes to stay with her.

Unlike the book, the film received negative reviews. O'Donnell's performance as Beth has been criticized for being "over the top." Howard Stern, Variety, and Opie and Anthony all commented that O'Donnell sounded like Pee-Wee Herman.

(Summary from Wikipedia)

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