Wise Blood is an American 1979 drama film directed by John Huston and based on the 1952 novel Wise Blood by Flannery O'Connor. It was filmed mostly in and around Macon, Georgia, near O'Connor's home Andalusia in Baldwin County, using many local residents as extras. Though largely faithful to O'Connor's novel, Huston reframes many scenes from the book as broad comedy accompanied by a bluegrass banjo score. The original music score was composed by Alex North. The film was titled Der Ketzer or Die Weisheit des Blutes when released in Germany, and Le Malin when released in France.
(Summary from Wikipedia)